A Review Of Pharmacological Activities Of Pagoda Flower Plant (Clerodendrum paniculatum L.)
Keywords:
Pagoda Flower, Clerodendrum paniculatum, secondary metabolites, pharmacological activity
Abstract
Pagoda flower (Clerodendrum paniculatum L.) is a plant that can be used as traditional medicine, it is easy to obtain and cultivate. This plant contains flavonoids, tannins, steroids, and terpenoids. This study aimed to examine the pharmacological activity of the Pagoda Flower plant (Clerodendrum paniculatum L.) from various articles collected. The method used was the literature study. Search online using Google Scholar, Pubmed with the keywords used in this search being the key "Clerodendrum paniculatum activity". After a search has been carried out and the data source obtained, the data is then reviewed to obtain the literature that will be used in the article. The Pagoda Flower Plant (Clerodendrum paniculatum L.) has pharmacological effects such as antiaging, antidiabetic, antioxidant, anti-inflammatory, anticancer, antihyperlipidemia, antibacterial, and antifungal. All parts of the Pagoda Flower plant contain flavonoids, tannins, steroids, and terpenoids which produce various pharmacological activities.
References
1. Shrivastava N, Patel T. 2007. Clerodendrum and Heathcare: An Overview. Medical and Aromatic Plant Science and Biotechnology. 2007;1(1): 142-150.
2. Wang JH, Luan F, He XD, Wang Y, Li MX. Traditional Uses and Pharmacological Properties of Clerodendrum Pyhtochemical. J Tradit Complement Med. 2018; 8(1): 24-38
3. Kalonio DE, Hendriani R, Barung EN. Aktivitas Antikanker Tanaman Genus Clerodendrum (Lamiaceae): Sebuah Kajian. Trad. Med. J. 2017; 22(3): 182-189.
4. Hafiz I, Rosidah, Silalahi J. Antioxidant and Anti-inflammatory Activity of Pagoda Leaves (Clerodendrum paniculatum L.) Ethanolic Extract in White Male Rats (Rattus novergicus). International Journal of PharmTech Research. 2016; 9(5): 165-170.
5. Rathee P, Chaudhary H, Rathee S, Rathee D, Kumar V, Kohli K. Mechanism of Action of Flavonoids as Anti-Inflammatory Agents: A Review. Inflamm allergy-drug targets. 2009 Jul; 8(3): 229-235.
6. Leena PN, Aleykutty NA. Comparative Study on Antibacterial Activities of Clerodendrum informtunatum Linn and Clerodendrum paniculatum Linn Root Extract. IJAPBC. 2012; 1(3): 325-327.
7. Krishnan DR, Vijayakumar M, Sandeep VR, Ilavarasu A, Dhanabal SP. In VitroAanti-Skin Ageing Benefits of Clerodendrum paniculatum Leaf Extract. World Journal of Pharmaceutical Research. 2017; 6(7): 1645-1657
8. Rumanti RM, Firti K, Kumala R, Leny, Hafiz I. Formulasi Sediaan Krim Anti Aging dari Ekstrak Etanol Daun Pagoda (Clerodendrum paniculatum L.). Majalah Farmasetika. 2022; 7(4): 288-304.
9. Ihsanul H, Mandike G. Antiinflammatory Activity of Pagoda Flower (Clerodendrum paniculatum L.) Ethanol Extract Using Paw Edema Method. Asian Journal of Pharmaceutical Research and Development. 2019; 7(6): 43-45
10. Hebbar DR, Devika M, Rashmi GN, Nalini MS. Phytochemicals and Antioxidant Activity of Clerodendrum paniculatum L. Leaf and Flower Extract. Asian J Pharm Clin Res. 2022; 15(1): 31-34.
11. Kopilakkal R, Chanda K, Balamurali MM. Hepatoprotective and Antioxidant Capacity of Clerodendrum paniculatum Flower Extracts against Carbon Tetrachloride-Induced Hepatotoxicity in Rats. ACS Omega. 2021; 6: 26489-26498.
12. Purwanto D, Bahri S, Ridhay A. Uji Aktivitas Antioksidan Ekstrak Buah Purnajiwa (Kopsia arborea Blume.) Dengan Berbagai Pelarut. Kovalen. 2017 April; 3(1): 24-32.
13. Ibrahim F, Prihantono, Ahmad M, Siagian NA. The Effect of Pagoda Leaves Extracts on the Level of IL-6 of Female Rats Induced by Staphylococcus Aureus. Health Notions. 2018; 2(5): 539-545.
14. Suriati I, Ahmad M, Siagian NA, Prihantono. The Effect of Pagoda Leaf Extract (Clerodendrum paniculatum L.) on The Level IL-10 in Mammae of Female Rats Strain (Sprague Dawley) Induced with Staphylococcus aureus Bacteria. Qanun Medika. 2019; 3(1): 63-74
15. Joseph J, Bindhu AR, Aleykutty NA. In Vitro and In Vivo Antiinfalmmatory Activity of Clerodendrum Paniculatum Linn. Leaves. Indian J Pharm Sci. 2013; 75(3): 376-379.
16. Marbun EMA, Restuati M. Pengaruh ektrak etanol daun buasbuas (Premna pubescens Blume) sebagai antiinflamasi pada edema kaki tikus putih (Rattus novergicus). J Biosains. 2015; 1(3):107- 112.
17. Nurhamidin SJ, Wewengkang DS, Suoth EJ. Uji Aktivitas Ekstrak dan Fraksi Organisme Laut Spons Aaptos aaptos Terhadap Bakteri Escherichia coli dan Staphylococcus aureus. Pharmacon. 2022 Feb; 11(1): 1285-1291.
18. Pertiwi D, Sitorus P, Hafiz I. Antimicrobial Activity of Clerodendrum paniculatum L. n-Hexane and Water Fraction Against Pseudomonas aerugonisa and MRSA. IJPST. 2022; 9(6): 22-31.
19. Abdullah E, Raus RA, Jamal P. Extraction and evaluation of antibacterial activity from selected flowering plants, American Medical Journal. 2012; 3(1): 27-32.
20. Praveen M, Radha K, Hari KR, Padmaja V, Mathew A, Ajith KP. Preliminary Phytochemical, Antimicrobial and Toxicity Studies on Clerodendrum paniculatum Linn leaves. Hygeia J D Med. 2012; 4(1): 41-50
21. Shruthi G, Joyappa MP, Chandrashekhar S, Kollur SP, Prasad MNN, Prasad A, Shivamallu C. Bactericidal Property of Clerodendrum paniculatum and Saraca asoka Againts Multidrug Resistant Bacteria, Reatoring the Faith in Herbal Medicine. 2017; 8(9): 3863-3871.
22. Suriaman E, Permana ASH, Warman M. Aktivitas Antibakteri Ekstrak Etanol Buah Mentimun (Cucumis sativus Linn.) terhadap Salmonella typhi dan Bacillus cereus Secara In Vitro. Stigma J Sci. 2016; 9(1): 1–5
23. Ningsih IS, Chatri M, Advinda L, Violita. Senyawa Aktif Flavonoid yang Terdapat Pada Tumbuhan. Serambi Biologi. 2023. 8(2): 126-132.
24. Warganegara E, Restina D. Getah Jarak (Jatropha curcas L.) sebagai Penghambat Pertumbuhan Bakteri Streptococcus mutans pada Karies Gigi. Majority. 2016 Sept; 5(3): 62-67.
25. Robinson T. Kandungan Organik Tumbuhan Tingkat Tinggi. 1995. Bandung; Institut Teknologi Bandung: 367
26. Sofyani, R. F. 2017. Potensi Ekstrak Daun Pagoda (Clerodendrum japonicum [Tumb.] Sweet) Sebagai Antikanker Dengan Metode Brine Srimp Lethality Test (BSLT). Skripsi. Malang: Akademi Farmasi Putra Indonesia.
27. Pertiwi D, Hafiz I, Leny. Potential Bioactivities of Ethanol, Ethyl Acetate and n-Hexane Extracts from Pagoda Leaves (Clerodendrum paniculatum L.). Rasayan J. Chem. 2020; 13(4): 2313-2316.
28. Yasir B, Astuti AD, Raihan M, Natzir R, Subehan, Rohman A, Alam G. Optimization of Pagoda (Clerodendrum paniculatum L.) Extraction Based by Analytical Factorial Design Approach, Its Phytochemical Compound, and Cytotoxicity Activity. Egypt. J. Chem. 2022; 65(9): 421-430.
29. Hegde NP, Hungund BS. Phytochemical Profiling of Clerodendrum paniculatum Leaf Extracts: GC-MS, LC-MS Analysis and Comparative Evaluation of Antimicrobial, Antioxidant & Cytotoxic Effects. Natural Product Research. 2023; 37(17): 2957-2964.
2. Wang JH, Luan F, He XD, Wang Y, Li MX. Traditional Uses and Pharmacological Properties of Clerodendrum Pyhtochemical. J Tradit Complement Med. 2018; 8(1): 24-38
3. Kalonio DE, Hendriani R, Barung EN. Aktivitas Antikanker Tanaman Genus Clerodendrum (Lamiaceae): Sebuah Kajian. Trad. Med. J. 2017; 22(3): 182-189.
4. Hafiz I, Rosidah, Silalahi J. Antioxidant and Anti-inflammatory Activity of Pagoda Leaves (Clerodendrum paniculatum L.) Ethanolic Extract in White Male Rats (Rattus novergicus). International Journal of PharmTech Research. 2016; 9(5): 165-170.
5. Rathee P, Chaudhary H, Rathee S, Rathee D, Kumar V, Kohli K. Mechanism of Action of Flavonoids as Anti-Inflammatory Agents: A Review. Inflamm allergy-drug targets. 2009 Jul; 8(3): 229-235.
6. Leena PN, Aleykutty NA. Comparative Study on Antibacterial Activities of Clerodendrum informtunatum Linn and Clerodendrum paniculatum Linn Root Extract. IJAPBC. 2012; 1(3): 325-327.
7. Krishnan DR, Vijayakumar M, Sandeep VR, Ilavarasu A, Dhanabal SP. In VitroAanti-Skin Ageing Benefits of Clerodendrum paniculatum Leaf Extract. World Journal of Pharmaceutical Research. 2017; 6(7): 1645-1657
8. Rumanti RM, Firti K, Kumala R, Leny, Hafiz I. Formulasi Sediaan Krim Anti Aging dari Ekstrak Etanol Daun Pagoda (Clerodendrum paniculatum L.). Majalah Farmasetika. 2022; 7(4): 288-304.
9. Ihsanul H, Mandike G. Antiinflammatory Activity of Pagoda Flower (Clerodendrum paniculatum L.) Ethanol Extract Using Paw Edema Method. Asian Journal of Pharmaceutical Research and Development. 2019; 7(6): 43-45
10. Hebbar DR, Devika M, Rashmi GN, Nalini MS. Phytochemicals and Antioxidant Activity of Clerodendrum paniculatum L. Leaf and Flower Extract. Asian J Pharm Clin Res. 2022; 15(1): 31-34.
11. Kopilakkal R, Chanda K, Balamurali MM. Hepatoprotective and Antioxidant Capacity of Clerodendrum paniculatum Flower Extracts against Carbon Tetrachloride-Induced Hepatotoxicity in Rats. ACS Omega. 2021; 6: 26489-26498.
12. Purwanto D, Bahri S, Ridhay A. Uji Aktivitas Antioksidan Ekstrak Buah Purnajiwa (Kopsia arborea Blume.) Dengan Berbagai Pelarut. Kovalen. 2017 April; 3(1): 24-32.
13. Ibrahim F, Prihantono, Ahmad M, Siagian NA. The Effect of Pagoda Leaves Extracts on the Level of IL-6 of Female Rats Induced by Staphylococcus Aureus. Health Notions. 2018; 2(5): 539-545.
14. Suriati I, Ahmad M, Siagian NA, Prihantono. The Effect of Pagoda Leaf Extract (Clerodendrum paniculatum L.) on The Level IL-10 in Mammae of Female Rats Strain (Sprague Dawley) Induced with Staphylococcus aureus Bacteria. Qanun Medika. 2019; 3(1): 63-74
15. Joseph J, Bindhu AR, Aleykutty NA. In Vitro and In Vivo Antiinfalmmatory Activity of Clerodendrum Paniculatum Linn. Leaves. Indian J Pharm Sci. 2013; 75(3): 376-379.
16. Marbun EMA, Restuati M. Pengaruh ektrak etanol daun buasbuas (Premna pubescens Blume) sebagai antiinflamasi pada edema kaki tikus putih (Rattus novergicus). J Biosains. 2015; 1(3):107- 112.
17. Nurhamidin SJ, Wewengkang DS, Suoth EJ. Uji Aktivitas Ekstrak dan Fraksi Organisme Laut Spons Aaptos aaptos Terhadap Bakteri Escherichia coli dan Staphylococcus aureus. Pharmacon. 2022 Feb; 11(1): 1285-1291.
18. Pertiwi D, Sitorus P, Hafiz I. Antimicrobial Activity of Clerodendrum paniculatum L. n-Hexane and Water Fraction Against Pseudomonas aerugonisa and MRSA. IJPST. 2022; 9(6): 22-31.
19. Abdullah E, Raus RA, Jamal P. Extraction and evaluation of antibacterial activity from selected flowering plants, American Medical Journal. 2012; 3(1): 27-32.
20. Praveen M, Radha K, Hari KR, Padmaja V, Mathew A, Ajith KP. Preliminary Phytochemical, Antimicrobial and Toxicity Studies on Clerodendrum paniculatum Linn leaves. Hygeia J D Med. 2012; 4(1): 41-50
21. Shruthi G, Joyappa MP, Chandrashekhar S, Kollur SP, Prasad MNN, Prasad A, Shivamallu C. Bactericidal Property of Clerodendrum paniculatum and Saraca asoka Againts Multidrug Resistant Bacteria, Reatoring the Faith in Herbal Medicine. 2017; 8(9): 3863-3871.
22. Suriaman E, Permana ASH, Warman M. Aktivitas Antibakteri Ekstrak Etanol Buah Mentimun (Cucumis sativus Linn.) terhadap Salmonella typhi dan Bacillus cereus Secara In Vitro. Stigma J Sci. 2016; 9(1): 1–5
23. Ningsih IS, Chatri M, Advinda L, Violita. Senyawa Aktif Flavonoid yang Terdapat Pada Tumbuhan. Serambi Biologi. 2023. 8(2): 126-132.
24. Warganegara E, Restina D. Getah Jarak (Jatropha curcas L.) sebagai Penghambat Pertumbuhan Bakteri Streptococcus mutans pada Karies Gigi. Majority. 2016 Sept; 5(3): 62-67.
25. Robinson T. Kandungan Organik Tumbuhan Tingkat Tinggi. 1995. Bandung; Institut Teknologi Bandung: 367
26. Sofyani, R. F. 2017. Potensi Ekstrak Daun Pagoda (Clerodendrum japonicum [Tumb.] Sweet) Sebagai Antikanker Dengan Metode Brine Srimp Lethality Test (BSLT). Skripsi. Malang: Akademi Farmasi Putra Indonesia.
27. Pertiwi D, Hafiz I, Leny. Potential Bioactivities of Ethanol, Ethyl Acetate and n-Hexane Extracts from Pagoda Leaves (Clerodendrum paniculatum L.). Rasayan J. Chem. 2020; 13(4): 2313-2316.
28. Yasir B, Astuti AD, Raihan M, Natzir R, Subehan, Rohman A, Alam G. Optimization of Pagoda (Clerodendrum paniculatum L.) Extraction Based by Analytical Factorial Design Approach, Its Phytochemical Compound, and Cytotoxicity Activity. Egypt. J. Chem. 2022; 65(9): 421-430.
29. Hegde NP, Hungund BS. Phytochemical Profiling of Clerodendrum paniculatum Leaf Extracts: GC-MS, LC-MS Analysis and Comparative Evaluation of Antimicrobial, Antioxidant & Cytotoxic Effects. Natural Product Research. 2023; 37(17): 2957-2964.
Published
2023-12-30
How to Cite
Banne, Y., Rindengan, E., Lesawengen, R., Maramis, R., & Sapiun, Z. (2023). A Review Of Pharmacological Activities Of Pagoda Flower Plant (Clerodendrum paniculatum L.). PROSIDING SEMINAR NASIONAL, 2, 50 - 63. Retrieved from https://ejurnal.poltekkes-manado.ac.id/index.php/prosiding2023/article/view/2234
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Articles
